Results
PMID | 11821088 |
Gene Name | PGR |
Condition | Endometriosis |
Association |
Associated |
Mutation | 306-base pair insertion polymorphism in intron G of PROGINS |
Population size | 202 |
Population details | 202 (107 white women without endometriosis, 95 women with surgically diagnosed and histologically confirmed endometriosis) |
Sex | Female |
Associated genes | PROGINS |
Other associated phenotypes |
Endometriosis |
Fertil Steril. 2002 Feb;77(2):309-12. Wieser, Fritz| Schneeberger, Christian| Tong, Dan| Tempfer, Clemens| Huber, Johannes C| Wenzl, Rene Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, University of Vienna, Waeringer Guertel 18-20, A-1090 Vienna, Austria. OBJECTIVE: To investigate the association between the 306-base pair insertion polymorphism in intron G of the progesterone receptor (PROGINS) and endometriosis. DESIGN: Case-control study. SETTING: Tertiary care center. PATIENT(S): Ninety-five white women with surgically diagnosed and histologically confirmed endometriosis and 107 white women without endometriosis (controls). INTERVENTION(S): Determination of PROGINS was performed by polymerase chain reaction and gel electrophoresis. MAIN OUTCOIME MEASURE(S): Frequency and distribution of the PROGINS allele. RESULT(S): Frequencies of the mutant allele T2 was 0.17 among women with endometriosis and 0.08 among controls (odds ratio, 2.41 [CI, 1.31-4.53]). Homozygosity for allele T2 was present in 3.2% of women with endometriosis and 0.9% of controls. CONCLUSION(S): PROGINS appears to be associated with endometriosis in white persons. Mesh Terms: Adult| Case-Control Studies| DNA/chemistry/*genetics/isolation & purification| Electrophoresis, Agar Gel| Endometriosis/*genetics| Female| Humans| Middle Aged| Polymerase Chain Reaction| Polymorphism, Genetic/genetics| Receptors, Progesterone/*g |